El-Sisi is also set to meet with Republican and Democratic members of an "Egypt's friends" group in Congress, said Presidential Spokesman Bassam Rady on Wednesday.
At the Washington Convention Center, the Egyptian president will have one-on-one talks with US Secretary of State Antony Blinken, Rady added.
Later in the day, El-Sisi will attend a banquet organised by US President Joe Biden at the White House in honour of African leaders taking part in the US-Africa summit.
The president is scheduled to attend the closing session of the US-Africa Business Forum (USABF) in the presence of Biden, Rady added.
The US-Africa Summit, hosted by Biden, is the second after the first in the US capital in 2014.
The summit runs for through Thursday with the participation of nearly 49 heads of state and senior government officials from African countries.
El-Sisi will be focusing on a host of issues of concern to African countries amid the existing global challenges to strengthen African-American partnership to confront the food security crisis, Rady said on Tuesday.
El-Sisi will also stress on means to facilitate the integration of African countries into the global economy to benefit from the available opportunities to achieve economic growth, transfer technology, and drive foreign investment.
He is set to discuss ways to strengthen relations between Egypt and the US with a number of senior US officials to achieve common interests and tackle regional and international issues of mutual interest, the statement added.
The Egyptian president's programme includes meeting with the US business community to discuss means of advancing cooperation in the economic, trade, and investment fields.
He will also meet a number of heads of state and government participating in the summit to exchange views on various regional and international issues, Rady added.
The summit is set to witness discussion on new initiatives to increase US engagement with the African Continental Free Trade Area (AfCFTA), read a previous statement by the African Union (AU) Mission to the US.
It is also set to tackle initiatives to boost the continent’s recovery from COVID-19, bolster food security, and promote investment in infrastructure, health, and renewable energy projects, among other priorities, added the AU mission.
The three-day summit is divided into a Civil Society Day on Tuesday, a Business Day on Wednesday, and a Leaders Day for government meetings and events for visiting country delegations on Thursday.
The second day comprises the USABF, hosted by the US Department of Commerce, the US Chamber of Commerce, and the Corporate Council on Africa, in partnership with the Prosper Africa initiative.
The USABF will focus on advancing two-way trade and investment partnership to bolster Africa’s role in the global economy, scale innovation and entrepreneurship, and drive advancements in key sectors.