Two workers were killed and 22 others injured on Saturday when a bus driving them to a factory in 10th of Ramadan City in the outskirts of Cairo collided into another bus.
Those hurt with injuries of fractions, bruises and wounds, were transferred to a nearby hospital, Al-Ahram Arabic news website reported.
The road accident comes a day after seven people, including four children, were killed in a collision between a train and a school bus. Some 24 others were injured.
Friday's crash occurred on a motorway connecting the capital Cairo and the coastal city of Ismailia.
Accidents at railway crossings and on high roads are regular occurences in Egypt due to ill-maintained roads and careless driving.
A deadly collision in Assiut in 2012 killed 51 people, mostly children, when a train hit a school bus, while in 2013, 30 people died when a minibus collided with a train just south of Cairo.