Six people were killed and five injured when two cars and six motorbikes collided in Heliopolis in Cairo on Friday, MENA agency reported.
All casualties were aged between 19 and 21 years old.
Those injured were transported to the nearest hospital, Galaa military hospital.
Deadly road crashes take place on a near daily basis in Egypt, which is notorious for poor road safety, badly maintained infrastructure, and loosely enforced traffic regulations.
The country's official statistics agency said in December that over 2800 people were killed in road and train crashes in Egypt in the first half of 2015.