A man was killed and his mother seriously injured when their mud-brick house collapsed in Menoufiya governorate, north of Cairo, Egypt's state news agency MENA reported.
The small two-storey building was made of mud-brick and had a wooden ceiling.
This is the second such incident to be reported this week.
On Tuesday, a builder was killed and six others injured when the ceiling of an under-construction mosque collapsed in a town in Fayoum, south of Cairo.
Building collapses are not uncommon in Egypt and are usually attributed to violations of building regulations, illegal building extensions, and lax government oversight.
Last week, two people were killed and four others injured when two buildings collapsed in Cairo's district of Rod El-Farag.