At least seven people were killed and nine were injured when a microbus and a truck collided on a ring road leading to Minya's Western Desert road in Upper Egypt.
The bodies of the victims and the injured have been taken to hospital.
The deadly crash comes days after at least 13 people were killed and seven others were wounded in a road accident in the southern governorate of Aswan.
Deadly road crashes take place nearly daily in Egypt, mostly due to poor road safety, badly maintained infrastructure, and loosely enforced traffic regulations. They claim thousands of lives every year.
More than 1,500 people were killed in road accidents in Egypt in the first half of 2019, according to official statistics agency CAPMAS. Some 5,220 accidents took place in the first six months of the year, up almost 18 percent from the same period in 2018.
The government has allocated millions of pounds to developing and expanding road networks in recent years.
A comprehensive traffic law designed to crack down on violators and enhance safety is set to go into effect this year.