Yaakov Amitai, Israeli ambassador to Egypt, left Cairo Thursday morning on an Air Sinai flight for his regular weekend break in Israel.
The move comes hours before the Supreme Constitutional Court is expected to deliver its verdict on the Political Disenfranchisement Law and Egypt's electoral law.
The court's decision could disqualify Ahmed Shafiq from the presidential race just two days before the runoff is scheduled to take place.
Amitai returns to Cairo every Monday to resume his work, according to MENA, Egypt's state-owned media agency.
In September 2011, protesters attacked the Israeli embassy in Cairo, prompting the abrupt evacuation of all embassy staff. Since then, Israeli embassy officials have worked in Cairo from offices in Maadi, New Cairo and near the Cairo International Airport.