The spokesmen for the Egyptian presidency and the cabinet quit on Tuesday, the latest in a string of resignations from the administration of President Mohamed Morsi, who is facing massive public pressure to step down.
Presidential spokesman Ehab Fahmy - who was seconded to the presidency from the foreign ministry - has tendered his resignation, a foreign ministry official told AFP.
Cabinet spokesman Alaa El-Hadidi told the official MENA news agency he had also given his notice to Prime Minister Hisham Qandil.
Five Egyptian ministers have resigned since Sunday's mass nationwide protests demanding the president's removal.
On Monday, eight members of the Islamist-dominated Shura Council stepped down in protest at the simmering political stand-off in the country.
Former armed forces chief-of-staff Sami Anan also stood down as a presidential advisor on the same day, in solidarity with the opposition's demands.