FILE -- In This April 21, 2014, file photo, provided by the anti-government activist group Aleppo Media Center (AMC), which has been authenticated based on its contents and other AP reporting, shows a Syrian man holding a girl as he stands on the rubble of houses that were destroyed by Syrian government forces air strikes in Aleppo, Syria. (AP Photo/Aleppo Media Center AMC, File)
Islamic State militants entered a Syrian opposition stronghold in the country's north on Saturday, clashing with rebels on the edges of the town as the extremist group built on its most significant advance near the Turkish border in two years, Syrian opposition groups and IS group media said.
More than 160,000 civilians are trapped in the fighting, which also forced the evacuation of one of the few remaining hospitals in the area, run by the international medical organization Doctors Without Borders.
On Saturday, IS group fighters staged two suicide bombings targeting "opposition forces" near Marea, IS group said via its news agency, Aamaq.
Following the suicide bombings, IS group militants entered Marea and fighting began inside the town, according to the Syrian Observatory for Human Rights, a Britain-based opposition media outfit that tracks Syria's civil war.
The territorial gains around the rebel strongholds of Marea and Azaz, north of Aleppo city, are a blow to the Turkey and Saudi-backed rebels, who have been struggling to retain a foothold in the region while being squeezed by opponents from all sides. They also demonstrated the Islamic State group's ability to stage major offensives and capture new areas, despite a string of recent losses in Syria and Iraq.
The IS group offensive targeting Syrian opposition strongholds near the Turkish border began Thursday night.
On Friday, militants of the group captured six villages near Azaz, triggering intense fighting that trapped tens of thousands of civilians unable to flee to safety while Turkey's border remains closed. A few hundred fled west to the Kurdish-held enclave of Afrin.
People are "terrified for their lives," the International Rescue Committee said in a statement. The group said it has received confirmed reports that at least four entire families, including women and children, were killed Friday on the outskirts of the town of Azaz.
The IRC runs centers for both children and women in Azaz and provides clean water and sanitation to a camp supporting 8,500 people. More than half the camp's population has left to find safety elsewhere in the town, it said. The IRC also relocated its staff from the centers and camp to shelter to safer areas of Azaz until the situation enables them to return.
The U.N. refugee agency said it was "deeply concerned" about the fighting affecting thousands of vulnerable civilians.
"Fleeing civilians are being caught in crossfire and are facing challenges to access medical services, food, water and safety," it said in a statement Saturday.
The advances brought the militants to within few kilometers of the rebel-held town of Azaz and cut off supplies to Marea further south. Marea has long been considered a bastion of moderate Syrian revolutionary forces fighting to topple President Bashar Al-Assad.
Azaz, which hosts tens of thousands of internally displaced people, lies north of Aleppo city, which has been divided between a rebel-held east and government-held west.
A route known as the Azaz corridor links rebel-held eastern Aleppo with Turkey. That has been a lifeline for the rebels since 2012, but a government offensive backed by Russian air power and regional militias earlier this year dislodged rebels from parts of Azaz and severed their corridor between the Turkish border and Aleppo.
The predominantly Kurdish Syrian Democratic Forces (SDF), who are fighting for their autonomy in the multilayered conflict, also gained ground against the rebels.
In recent months, Syrian rebel factions in Azaz — which include mainstream opposition fighters known as the Free Syrian Army along with some ultraconservative Islamic insurgent factions — have been squeezed between IS group to the east and predominantly Kurdish forces to the west and south, while Turkey restricts the flow of goods and people through the border.