An aerial view shows smoke billowing from a warehouse after reported shelling on the town of Sarmada in Syria s northwestern Idlib province on October 16, 2021. AFP
The strike comes two days after a base in southern Syria, used by the US-led coalition fighting the Islamic State group, was assaulted.
"A US airstrike today in northwest Syria killed senior al-Qaeda leader Abdul Hamid al-Matar," said Central Command spokesman Army Major John Rigsbee in a statement.
There were no known casualties from the strike, he said, adding it was conducted using an MQ-9 aircraft.
"The removal of this al-Qaeda senior leader will disrupt the terrorist organization's ability to further plot and carry out global attacks," he said.
At the end of September the Pentagon killed Salim Abu-Ahmad, another senior Al-Qaeda commander in Syria, in an airstrike near Idlib in the country's northwest.
He had been responsible for "planning, funding, and approving trans-regional Al-Qaeda attacks," according to Centcom.
"Al-Qaeda continues to present a threat to America and our allies. Al-Qaeda uses Syria as a safe haven to rebuild, coordinate with external affiliates, and plan external operations," Rigsbee said.
The ongoing war in Syria has created a complex battlefield involving foreign armies, militias and jihadists.
The war has killed around half a million people since starting in 2011 with a brutal crackdown on anti-government protests.