A bomb attack that killed three top security chiefs in Damascus marks "the beginning of the end of the regime" of President Bashar al-Assad, an opposition spokesman said on Thursday.
"We see that what happened (on Wednesday) is a sign of the beginning of the end of the regime," Syrian National Council spokesman George Sabra told AFP.
"It was a major blow to (Assad) and the regime's repressive security apparatus."
A blast in the National Security headquarters in the heart of Damascus on Wednesday killed three top regime officials -- Assad's brother-in-law Assef Shawkat, defence minister Daoud Rajha and the regime's crisis cell chief Hassan Turkmani.
The attack took place as fierce fighting has engulfed several districts of Damascus since Monday when an all-out assault was launched by rebel Free Syrian Army to capture the capital. The group has claimed responsibility for Wednesday's bombing.
The strike "shows that (Assad's) regime cannot play any role in Syria's future, and that it is a part of the past," said Sabra.
"I consider that the Syrian people are now getting ready to welcome new reports that indicate that the authorities are losing power not just in the provinces and towns, but also in military and security institutions."
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