File Photo: Chicks are seen at a poultry farm in Pruille-le-Chetif near Le Mans, France, March 4, 2020. Picture taken March 4, 2020. Reuters
The country has been hit by several epidemics since 2015 but they have mainly been contained to the southwest, where ducks are bred for the lucrative foie gras liver pate industry.
But this winter, for the first time, wild birds migrating back from the south contaminated farmed poultry, sparking the second wave of infections only now coming to an end.
Nearly 1,400 sites have reported cases, including at least 850 in the Vendee, considered strategic by the ministry because it is home to many farms that raise chickens and other birds exclusively for breeding.
However the outbreak peaked at the end of March and the disease's spread is slowing, the ministry said.
Culling in such large numbers generates substantial costs, both for farmers as production grinds to a halt and export markets close, and for the state which compensates the farmers for their losses.
Egg production has dropped around 6 percent since November as a result of the outbreak, according to the vice-president of the Egg Committee (NCPO) Loic Coulombel.
Last year, nearly 500 sites reported bird flu cases, and 3.5 million animals - mainly ducks - were culled.