Investors are keeping a close eye on London, after new finance minister Kwasi Kwarteng's tax-cutting last week sent shock waves through markets, pushing the pound to a record low and leading to dire warnings for Britain's economy.
While Asia saw small gains Tuesday, New York and Europe ended mostly in the red again, with Wall Street jolted by data showing a surprise improvement in US consumer confidence -- likely because of a dip in petrol prices -- and a jump in home sales.
The figures pointed to resilience in the world's top economy despite three successive bumper Federal Reserve rate hikes -- and expectations for another in November -- as it tries to tame four-decade-high inflation.
Several Fed officials have lined up this week to reassert their determination to keep hiking until prices are brought under control, even at the cost of a recession.
Observers are now betting that borrowing costs will top out at around 4.75 percent next year, and some policymakers have suggested they could remain elevated for some time.
The prospect of such tight monetary policy has battered equities, as US 10-year Treasury yields -- a gauge of future rates -- hit four percent for the first time since 2010.
The Dow and S&P 500 ended down Tuesday, though the Nasdaq enjoyed a slight uptick.
Asia resumed its downtrend Wednesday, with Hong Kong down more than three percent, while Seoul, Taipei and Manila sank more than two percent. Tokyo, Shanghai and Singapore were off more than one percent.
There were also losses in Sydney, Wellington, Bangkok and Mumbai, while London, Paris and Frankfurt were also sharply lower.
Russia nuclear warning
The dollar remains the go-to unit as the Fed leads the way in central bank tightening.
"The fact we have such a strong increase in US yields is attracting flows into the US dollar," said Nannette Hechler-Fayd'herbe, of Credit Suisse Group AG.
"As long as monetary and fiscal policy worldwide are really not coming to strengthen their own currencies, we should be anticipating a very strong dollar."
The greenback rose against sterling, with the British currency battered by concerns that Kwarteng's spending plan would ramp up borrowing just as the Bank of England was trying to hike rates to fight inflation, causing consternation among many observers.
The dollar was also approaching 145 yen, having sunk from a high close to 146 yen after the Japanese government intervened last week to support its currency.
Sentiment was also rattled by worries about developments in Ukraine, after Kremlin-installed authorities in four regions under Russian control claimed victory in annexation votes, with Moscow warning it could use nuclear weapons to defend the territories.
Ukraine and its allies have denounced the so-called referendums as a sham, saying the West would never recognise the results.
In response, Kyiv on Wednesday called for the West to "significantly" increase its military aid to Ukraine.
But former Russian leader Dmitry Medvedev -- an ally of President Vladimir Putin and now deputy chairman of the country's security council -- issued a stark warning that Moscow was ready to act decisively.
"I want to remind you -- the deaf who hear only themselves: Russia has the right to use nuclear weapons if necessary," he said on social media.
On crude markets, both main contracts were down more than two percent on recession worries and as Bloomberg quoted sources saying that US inventories increased more than four million barrels last week.
The drop comes despite a report that Moscow is calling on OPEC and other major groups to slash output by a million barrels a day when they meet next week.
"With Brent trading only a little above $80 and WTI below, you have to wonder how much more OPEC+ will tolerate, and the size of (any) output cut they may be considering next week in light of the new economic outlook and price," said OANDA's Craig Erlam.
Key figures at around 0810 GMT
Tokyo - Nikkei 225: DOWN 1.5 percent at 26,173.98 (close)
Hong Kong - Hang Seng Index: DOWN 3.4 percent at 17,250.88 (close)
Shanghai - Composite: DOWN 1.6 percent at 3,045.07 (close)
London - FTSE 100: DOWN 2.0 percent at 6,845.82
Pound/dollar: DOWN at $1.0680 from $1.0730 on Tuesday
Euro/dollar: DOWN at $0.9562 from $0.9595
Euro/pound: UP at 89.50 pence from 89.39 pence
Dollar/yen: DOWN at 144.60 yen from 144.81 yen
West Texas Intermediate: DOWN 2.2 percent at $76.76 per barrel
Brent North Sea crude: DOWN 2.1 percent at $84.50 per barrel
New York - Dow: DOWN 0.4 percent at 29,134.99 (close)