File photo: Former US President Donald Trump pumps his fist as he departs Trump Tower in New York on April 13, 2023. AFP
The 37 counts of the indictment -- released on Friday and focused on his alleged mishandling of classified materials -- set the former president up for a far more severe legal reckoning than the charges of personal, political and commercial misconduct he has largely ridden out in the past.
And it also sets the stage for a White House race like no other before it, with President Joe Biden's Department of Justice pursuing the prosecution of the clear front-runner for the Republican nomination.
Trump, who has already denounced what he insists is a politically-motivated witch hunt, is talking at two state Republican conventions in Georgia and then North Carolina, and is widely expected to use both platforms to attack the FBI and accuse federal prosecutors of unfairly targeting him.
The two events come just days before Trump is due to appear in federal court in Miami to answer the explosive charges he put US national security "at risk" by willfully retaining classified defense information, conspiring to obstruct justice, corruptly concealing documents, and making false statements.
The charges, brought by Justice Department Special Counsel Jack Smith, carry up to 20 years in prison each.
Trump has already responded to the indictment with a string of posts on his Truth Social platform and a video statement, calling Smith "deranged" and a "Trump hater" and framing the prosecution as election interference orchestrated by Biden and his campaign.
"They come after me because now we're leading in the polls again by a lot against Biden," he said.
So far, the response of many Republicans - including some of Trump's party nomination rivals - has been to rally behind the former president and amplify his sense of outrage.
The Speaker of the House of Representatives Kevin McCarthy, who has had a rollercoaster relationship with Trump, said the indictment marked a "dark day" for the United States.
"I, and every American who believes in the rule of law, stand with President Trump," McCarthy said.
And Florida Governor Ron DeSantis, seen as Trump's most viable challenger for the Republican ticket, echoed the claims of a "weaponized" Justice Department.