People rest outside the St Basil s cathedral in downtown Moscow on April 17, 2022. AFP
"According to our estimates, about 200,000 people are at risk of losing their jobs," Moscow Mayor Sergei Sobyanin said in a blog post.
He said authorities had last week approved a $41-million programme to support employment in the Russian capital.
"First of all, the programme is aimed at employees of foreign companies that have temporarily suspended their operations or decided to leave Russia," Sobyanin said.
Hundreds of mainly Western companies have announced the suspension of their activities or their departure from Russia after President Vladimir Putin sent troops to Ukraine on February 24.
Sobyanin said the newly approved programme was expected to support more than 58,000 people who have lost their jobs. Around 12,500 of them will undergo retraining, he added.
People in between jobs will be offered to get involved in public works in a number of city organisations, parks and elsewhere, Sobyanin added.
Economists believe that the worst economic impact of debilitating Western sanctions is still to come and expect Russia to plunge into a deep recession.