Ahly's team manager Mohamed Youssef asserted on Thursday that he is looking for a win during the upcoming Zamalek clash to secure a place in the Champions League's semis.
Ahly will host Zamalek on Sunday in the fifth match day of the competition's quarters. The match will take place in the Red Sea resort town of Gouna, 430km from the capital.
With only two matches remaining, Ahly are leading the group with seven points, three ahead of Cairo foes Zamalek.
"Ahly and Zamalek games know no predictions as it's a derby match between Egypt's biggest teams and the Champions League's most successful clubs," Youssef said in an interview conducted in English with CAF online on Thursday.
"Both teams know everything about each other so it's going to be a very tough game for both teams like all the derby games.
"Ahly enters every game with one goal which is to win, and that's what we're playing for on Sunday.
"Maximum points are our aim so that we guarantee our semi-final spot before leaving to South Africa to face Orlando Pirates in the final group match day.
"A derby win will boost our morale and help us to achieve a positive result against Pirates to win the group," Youssef concluded.
Ahly will face South Africa's Orlando Pirates in Johannesburg on the sixth match day, and the seven-time African champions are looking to guarantee their qualification to the competition's semis before the Johannesburg trip.
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