Omar El-Said (R) celebrates with Ahmed Zizo (C) one of Zamalek s goals in a 2-0 victory over Talae El-Geish (Ahram)
In carbon copy of the 2-0 victory over Enppi, Zizo converted a first-half penalty before setting up lone striker El-Said for a second three minutes past the hour mark.
Zizo was once again Zamalek's standout performer to take his tally to two goals and as many assists in the opening two matches as the defending champions made a fine start to the season.
Zamalek and Pyramids, who beat top-flight debutants Pharco 2-1, have six points on top of the table. Cairo giants Ahly could join them if they beat NBE club later in the day.
El-Geish are rooted to the bottom after failing to bag any point, having tasted a 3-0 defeat by NBE in their opening game.
French coach Patrice Carteron gave El-Said, who spent last season on loan at Gouna, a starting berth at the expense of Tunisian forward Seifeddine Jaziri and although he failed to exploit gaps behind El-Geish's backline, he remained dangerous in aerial duels.
Winger Mostafa Fathi, who returned from a loan spell at Smouha, was also included in the starting line-up but was largely a peripheral figure despite producing flashes of his skills.
Defender Mahmoud Alaa headed just wide from a corner after six minutes before Zamalek were awarded a dubious penalty on the quarter-hour mark after El-Said fell under the slightest of pushes from an opponent as he contested a cross.
Zizo, Zamalek's spot-kick specialist who was one of their key players in their triumphant league campaign last season, sent keeper Mohamed Bassam the wrong way to open the scoring.
El-Geish briefly applied some pressure in the early stages of the second half, which yielded a couple of half-chances.
However, Zamalek killed off their hopes when a long ball by defensive midfielder Tarek Hamed was superbly flicked by Zizo's outstretched leg to El-Said, who beat his marker to send a looping header in off the bar.
Moroccan winger Achraf Bencharki skewed his effort high over with the goal gaping after a low cross from compatriot Mohamed Ounajem was cleared into his path but Zamalek remained in the driving seat to claim an easy win.
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