Masry kicked off their Group C campaign with a convincing 0-0 draw away to Cameroon s Coton Sport last week (Photo: the club s official Twitter account)
Port Said-based club Masry, who host their matches in Alexandria, will be hoping to make the most of home advantage and beat their illustrious opponents.
Masry kicked off their Group C campaign with a convincing 0-0 draw away to Cameroon's Coton Sport last week while Mazembe defeated Congolese side AS Otoho 1-0 at home.
Although Mazembe's form has faded in recent years, they still boast vast experience in African competitions.
However, Masry's Tunisian coach Moine Chaabani believes his side have what it takes to win.
"Mazembe's team have big experience in African football but we are capable of producing a strong show," Chaabani, a two-time Champions League winner with Tunisia's Esperance, told the pre-match news conference.
"The support of Masry fans will be vital in spurring us against Mazembe."
The big-spending Pyramids, meanwhile, will be favourites to beat Zanaco and maintain their fine start to their Group A campaign.
The Emirati-owned club came from behind to beat Libya's Ahli Tripoli 2-1 at home while Zanaco lost 1-0 away to Tunisia's Sfaxien.
Pyramids are in buoyant mood after going top of the Egyptian Premier League with a 1-0 win over Ismaily on Wednesday, although second-placed Ahly still have two games in hand.
"We are ready to continue our winning streak as we aim to go clear on top of our Confederation Cup group," Pyramids coach Ihab Galal said.
"Zanaco are an experienced team and facing them away from home won't be easy. But our primary target is to finish on top of the group and go all the way in the competition."
Pyramids reached the Confederation Cup final in 2020 but lost to Morocco's RS Berkane 1-0. They were the victims of another Moroccan outfit a year later, slumping to a shootout defeat by Raja in the semi-final following a 0-0 aggregate draw.
Masry took part in the Confederation Cup for four straight years (2017-20), reaching the semi-final in 2018 and the quarters on their previous participation in 2020.
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