The defending champions are currently joint leaders of the table with archrivals Ahly (31 points both), but they played one match more than Ahly.
With the latter occupied with its continental engagements, Zamalek aim to go through the league summit to pile pressure on their rivals when they return to the domestic league.
The Egyptian Football Association (EFA) decided earlier this week to postpone two league games for Ahly in order to give the Red Devils a chance to focus on their crucial clash in the Champions League quarters against Raja de Casablanca of Morocco.
The White Knights managed to win in their four previous league games, and new coach Jesualdo Ferreira hopes to keep his side’s winning rhythm.
The mission will not be easy against a good team like Pharco FC, managed by Nuno Almeida, the former assistant of Zamalek coach Ferreira.
In this clash, Zamalek will miss the efforts of Moroccan winger Acharf Bencharki, who was suspended for two games after receiving a red card against Maqassa last week.
International defender Mahmoud Hamdi will also be out due to knee injury, but Ferreira will have an important boost with the return of international duo Ahmed Fatouh and Seif Jaziri.
Both missed Zamalek's two previous games, but they are ready for Tuesday’s clash.
Pharco FC defeated Zamalek in the league cup in January and they want to repeat their success.
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