Veteran winger Abdallah El-Saied secured the win for the Whites with a precise strike from outside the box just a minute before halftime.
The Cairo giants, winners of the 2023-2024 CAF Confederation Cup title, started the match with relentless pressure on the hosts to clinch victory in the first leg and alleviate pressure before the upcoming return fixture in Cairo next Friday.
"The most important thing for us was to win and achieve our target," Zamalek coach Gomes said after the game.
Hosts Police FC of Kenya could not breach Zamalek's resolute defense in search of an equalizer.
Despite notable summer acquisitions, Zamalek's coach Jose Gomes opted for a standard lineup, integrating young talents in lieu of seasoned players.
"We are now stronger than the previous season, thanks to spending more time with the team and preparing to play in the tournaments that we will participate in," the Portuguese coach added.
Conversely, Kenya's Police FC squandered a clear scoring opportunity against Zamalek, missing a crucial chance fifteen minutes before the final whistle, dashing hopes of leveling the score.
Kenya's Police FC earned their place in this round following a hard-fought 1-0 aggregate victory over Ethiopia Coffee SC.
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