The Egyptian side, who finished third in the Premier League last season to earn a spot in Africa’s secondary club competition, will kick off at 18:00 local time (GMT+3) at Cairo International Stadium.
Coach Yannick Ferrera is likely to rest several key players, giving fringe players a chance to feature after effectively securing qualification with the first-leg result.
Goalkeeper Mohamed Awad is expected to start in place of regular Mohamed Sobhi, while striker Seifeddine Jaziri could be named in the starting lineup after coming off the bench in the first leg.
Zamalek will again be without injured forwards Adam Kaied and Nasser Mansy, along with midfielder Mohamed Shehata.
Dekedaha, making their Confederation Cup debut, face a difficult task after their heavy defeat in the first leg.
The Somali club previously competed in the CAF Champions League in 2020, exiting in the preliminary round.
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