Egypt, leading Group C with a maximum nine points, are just one point short from sealing their spot in the continental competition.
In their previous encounter on Friday in Cairo, the Pharaohs clinched a 2-0 victory, with goals from Mahmoud 'Trezeguet' Hassan and Mohamed Salah.
However, Salah will be absent from the upcoming match as coach Hossam Hassan has chosen to rest him along with Nantes striker Mostafa Mohamed.
Hassan has various options to compensate the absence of these key players, including the possible inclusion of Zamalek winger Ahmed 'Zizo' Sayed on the right flank.
Zizo, who typically played as a right midfielder in Salah's presence, may revert to his original position on the right flank for this match.
During the last game, Mostafa Mohamed began on the bench as Hassan opted to start with Frankfurt forward Omar Marmoush, who has been in exceptional form in the Bundesliga, currently leading the scoring charts with eight goals.
Another potential option for Hassan is U-23 Egypt team and NBE Club striker Ossama Faysal, although starting with Marmoush appears to be the most probable choice.
In the previous clash, the Mauritanian national team displayed resilience, proving to be a serious challenge for the seven-time African champions, who took 70 minutes to break the deadlock.
The upcoming match in Nouakchott is anticipated to be tough, with the hosts expected to fiercely defend their chances in the qualifiers.
Mauritania, Botswana, and Cape Verde each have three points from three games.
Botswana will host Cape Verde in the group's other match, also scheduled for Tuesday.
The top two teams from the various groups in the Nations Cup qualifiers will advance to the continental competition.
(For more sports news and updates, follow Ahram Online Sports on Twitter at @AO_Sports and on Facebook at AhramOnlineSports.)
Short link: