First leg matches in parenthesis.

Friday 1 May

MK Etanchetie (DR Congo) 0-1 Warri Wolves (Nigeria) 1-2
Warri Wolves reach the next round with a 3-1 aggregate win 

Club Africain (Tunisia) 1-0 ASO Chlef (Algeria) 1-1
Scorer: Imad Miniaoui 43 
Club Africain reach the next round with a 2-1 aggregate win 

Saturday 2 May

Etoile du Sahel (Tunisia) 1-0 Young Africans (Tanzanie) 1-1
Scorer: Ammar Jemal 25
Etoile du Sahel reach the next round with a 2-1 aggregate win

Orlando Pirates (South Africa) 3-0 Mounana (Gabon) 2-2
Scorers: Kermit Erasmus 25, 28, 57
Orlando Pirates reach the next round with a 5-2 aggregate win

Sunday 3 May

Hearts of Oak (Ghana) 0-1 Djoliba (Mali) 2-1
Djoliba reach the next round on the away goal rule following a 2-2 aggregate draw

ASEC (Ivory Coast) 2-0 Onze Créateurs (Mali) 1-0

ASEC reach the next round after a 3-0 aggregate win

V.Club (DR Congo) 4-1 Royal Leopards (Swaziland) 0-1

V.Club reach the next round after a 4-2 aggregate win

FUS Rabat (Morocco) 2-3 Zamalek (Egypt) 0-0
Scorers: Marwane Saadane 40, Mourad Batna 72 / Bassem Morsi 15, Omar Gaber 84, Hazem Emam 90
Zamalek reach the next round after a 3-2 aggregate win

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