All times CLT (GMT+2)

Sunday 3 November

Bandari FC 0-1 Horoya A.C  (2-4)
Scorer: Ocansey Mandela 
Horoya AC.C advance to the group stage on a 5-2 aggregate win

Masry 2-0 COTE D'OR FC (4-0)
Scorers: Ahmed Gomaa 21, 78
Masry advance to the group stage on a 6-0 aggregate win

Zanaco FC Zanaco FC 5-1 Cano Sport Academy  (3-1)
Zanaco FC advance to the group stage on a 8-2 aggregate win

Proline Football Club 0-2 El Nasr (2-2)
El Nasr advance to the group stage on a 4-2 aggregate win

Triangle FC 3-2 FC Nouadhibou (0-2)
FC Nouadhibou advance to the group stage on a 4-3 aggregate win

TS Galaxy 1-2 Enyimba FC (0-2)
Enyimba advance to the group stage on a 4-1 aggregate win

DC Motema Pembe 2-1 Gor Mahia FC (1-1)
Motema Pembe advance to the group stage on a 3-2 aggregate win

Enugu Rangers 1-0 AS Kara (1-2)
Scorer: Chinonso 20 
Enugu Rangers advance to the group stage on the away goal rule after a 2-2 aggregate score.

Bidvest Wits 6-0 União Desportiva do Songo (2-1)
Bidvest Wits advance to the group stage on a 8-1 aggregate win.

Djoliba AC de Bamako 4-0 Elect Sport (1-0)
Djoliba AC de Bamako advance to the group stage on a 5-0 aggregate win. 

FC San Pedro 2-0 Asante Kotoko (0-1)
FC San Pedro advance to the group stage on a 2-1 aggregate win. 

Hassania Agadir 2-1 Green Eagles (1-1)
Hassania Agadir advance to the group stage on a 3-2 aggregate win. 

Renaissance Sportive de Berkane 5-0 FOSA JUNIORS (0-2)
Renaissance Sportive de Berkane advance to the group stage on a 5-2 aggregate win. 

Pyramids FC 3-0 Young Africans (2-1)
Pyramids FC advance to the group stage on a 5-1 aggregate win. 

21:45 Paradou A.C vs. Kampala Capital City Authority (0-0)

* First leg results between brackets