South Africa's Mamelodi Sundowns ended TP Mazembe's 12-year unbeaten home run in the African Champions League after beating them 2-1 on Saturday.
Peter Shalulile gave Sundowns a 67th-minute lead in Lubumbashi but veteran forward Tresor Mputu Mabi drew Mazembe level eight minutes from time.
However, winger Lyle Lakay scored a precious stoppage-time winner for Sundowns to mark Mazembe's first home defeat after 21 matches, a run stretching back to 2009.
One-time African Champions Sundowns are on top of Group B with maximum nine points, while TP Mazembe remain at the bottom with only two points from three games.
Elsewhere, Sudan's Al-Mereikh bagged their first point in Group A after playing out a 0-0 draw with Tanzanians side Simba.
Simba remain on top of the group with seven points, four ahead of DR Congo's Vita Club and Egypt's Ahly, who meet later on Saturday.
(For more sports news and updates, follow Ahram Online Sports on Twitter at @AO_Sports and on Facebook at AhramOnlineSports.)