All times GMT +2
Wednesday 28 April
Group A
ES Setif 1-0 Al Ahli
Scorer: Ali Alqmati 2 O.G
Enyimba 1-0 Orlando Pirates
Scorer: Olisemah 90+5
Group C
CS Sfaxien 0-0 Diaraf
Etoile du Sahel 2-1 Salitas
Scorers: Lahmar 6, Coulibaly 47/ Michailou 72
Group D
Pyramids FC 1-0 Namungo FC
Scorer: Ibrahim Adel 65
Raja Casablanca 2-0 Nkana FC
Scorers: Idbouiguiguine 18, Sadaoui 42
Thursday 29 April 27, 2021
Group B
JS Kabylie 2-1 NAPSA Stars FC
Scorers: Bencherifa 29, Boualia 57
RSB Berkane 2-1 Coton Sport
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