Central Africa stunned Nigeria with a 1-0 win last week (Photo: CAF s official Twitter account)
The Super Eagles slumped to a shock defeat by their modest opponents in Lagos last week but they ensured there won't be more upsets in Yaounde, which hosted their second meeting of a double-header because Central Africa's stadium did not meet CAF's criteria.
Glasgow Rangers defender Leon Balogun opened the scoring on 29 minutes and Napoli's in-form striker Victor Osimhen made sure of the win on the stroke of halftime.
Nigeria have nine points from four games but second-placed Cape Verde can trim the gap back to two points if they beat Liberia (three points) in the other Group C game later on Sunday. Central Africa are third on four points.
In the hotly-contested Group E, Mali and Uganda continued their race with narrows 1-0 wins over Kenya and Rwanda respectively.
Striker Ibrahima Kone scored Mali's winner against Kenya 10 minutes after the restart and Fahad Bayo netted the decisive goal for Uganda midway through the first half.
Mali top the group on 10 points, two ahead of Uganda with two matches remaining. Kenya (two points) and Rwanda (1 point) are out of contention for the final two-legged playoff.
(For more sports news and updates, follow Ahram Online Sports on Twitter at @AO_Sports and on Facebook at AhramOnlineSports.