Al-Ittihad (LBA) v JC Abidjan (CIV)
Note: Tie reduced to one leg in Mali because of security situation in Libya and Ivory Coast

Enyimba (NGR) v US Bitam (GAB) (0-0)

Mouloudia Alger (ALG) v Dynamos (ZIM) (1-4)

InterClube (ANG) v Al-Merreikh (SUD) (0-2)        

Djoliba (MLI) v Diaraf (SEN) (0-3)

ASPAC (BEN) v Esperance (TUN) (0-5)

Raja Casablanca (MAR) v Stade Malien (MLI) (1-2)

Zamalek (EGY) v Club Africain (TUN) (2-4)

Recreativo Caala (ANG) v Al-Hilal (SUD) (0-3)

Simba (TAN) v TP Mazembe (COD, holders) (1-3)

Kano Pillars (NGR) v Wydad Casablanca (MAR) (0-2)

ASFA Yennenga (BUR) v Entente Setif (ALG) (0-2)

Cotonsport Garoua (CMR) v Vita (COD) (1-0)

SuperSport Utd (RSA) v Al-Ahly (EGY) (0-2)

Young Buffaloes (SWZ) v Zesco Utd (ZAM) (0-5)

Matches to be played between 1 and 3 April

Note: ASEC Mimosas (CIV) eliminated Motor Action (ZIM) after tie reduced to a single match because of security situation in Ivory Coast