With an eight-point lead at the top of the table, Dortmund can claim their first Bundesliga title since 2002 if they win at bottom side Borussia Moenchengladbach and second-placed Leverkusen draw at home to Hoffenheim.
"Just like we have seen from them (Hoffenheim) this season, I don't expect to get much from the match at Leverkusen," Klopp told German daily Bild.
"We have heard the team have already abandoned their coach.
"(Marco) Pezzaiuoli won't be there in three games time."
Klopp insists Leverkusen will want to make up for their 5-1 drubbing at Bayern Munich last Sunday which extended Dortmund's lead at the top of the table.
"Leverkusen will want to make amends after their defeat in Munich," said the 43-year old Klopp.