The pair met five times last season and this preseason series between league winner and domestic cup champion provides two more, starting with Sunday's first-leg at the Santiago Bernabeu stadium followed by the return at the Camp Nou on Wednesday.
Lionel Messi is expected to lead Barcelona but the Spanish and European champions could be without key players like Xavi Hernandez, Gerard Pique and Sergio Busquets because of injury.
Madrid are waiting on the health of defender Sergio Ramos but new midfielder Nuri Sahin misses out.
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