The winner of the Clasico will go top of La Liga, while Germany's surprise Champions League contenders face off and Paris Saint-Germain cannot afford to be distracted by thoughts of Bayern Munich.
Real Madrid v Barcelona, Saturday 1900 GMT
Some say the Clasico has lost its lustre, but suddenly Spain's two giants meet for the chance to go top of La Liga, at least for 24 hours.
At the start of February they were 10 points behind leaders Atletico Madrid, each having played a game more. Atletico's form has since dipped, while Real and Barca have been relentless. Zinedine Zidane's reigning champions have won seven and drawn two of their last nine, while Barcelona are unbeaten in 19, including 16 wins.
Now Barcelona are just one point behind Atletico, while Real are three points behind the leaders but have the head-to-head advantage.
Even without fans at Real's training ground, the stakes are as high as they have been in this fixture in a long time.
Can Lionel Messi score against Real for the first time in three years after six games drawing blanks? Will Real be distracted by the prospect of their Champions League quarter-final return against Liverpool?
Germany's surprise top-four clash
Eintracht Frankfurt v Wolfsburg, Saturday 1330 GMT
Wolfsburg have not finished in the Bundesliga's top four since 2015, Eintracht since 1993. Both are on course to finish there this season, with the Wolves third and Frankfurt fourth.
Eintracht have lost just once in 16 games since Wolfsburg beat them 2-1 in December and last weekend's 2-1 win at Borussia Dortmund left them seven points clear of Erling Braut Haaland's team in fifth with seven matches left. Wolfsburg, four points better off, have lost once in 13.
Both are coached by an Austrian, with Eintracht's Adi Huetter and Wolfsburg's Oliver Glasner spending time at Red Bull Salzburg before leaving their home country. Their methods are not the same though: Wolfsburg's success is based on a solid defence, while only Bayern Munich have scored more goals than Frankfurt, whose leading marksman Andre Silva has 22 goals.
PSG play catch-up
Strasbourg v Paris Saint-Germain, Saturday 1500 GMT
PSG claimed a stunning win in the snow in Munich in their Champions League quarter-final first leg on Wednesday. The return leg is on Tuesday but in the meantime Mauricio Pochettino's side have a crucial trip to Strasbourg in Ligue 1.
A 1-0 defeat by Lille last weekend saw them slip three points behind their conquerors at the top with seven games left, while Monaco and Lyon are still in contention.
PSG have lost and drawn on their last two league visits to Alsace and go to the Stade de la Meinau without the suspended Neymar. The Parisians have already lost eight league games this season and must be wary of a Strasbourg team who recently drew in Lille and beat Monaco.
Atletico to respond?
Betis v Atletico Madrid, Sunday 1900 GMT
Diego Simeone's Atletico will know the outcome of the Clasico before taking to the field against Betis as they return to the city where they lost 1-0 against Sevilla last weekend.
In two months Atletico have seen a 10-point lead atop La Liga fritter away on a run of just four wins in 10, and they are without injured top scorer Luis Suarez as well as the suspended Marcos Llorente for the visit to sixth-placed Betis.
Lokomotiv Moscow v Spartak Moscow, Sunday 1600 GMT
Gazprom-backed Zenit Saint-Petersburg are on course to win a third straight Russian title, but if they are to slip up then a quartet of Moscow's grandees are queueing up.
Among them are second-placed Spartak and third-placed Lokomotiv, who meet on Sunday, with CSKA and Dynamo further back.
Lokomotiv are seeking a sixth straight win since the league came out of its long winter hibernation, while Spartak are looking for a fifth consecutive victory fuelled by the goals of Aleksandr Sobolev and Jordan Larsson, the Swedish son of Henrik rumoured to be a target for Dortmund.
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