Federico Chiesa s season is likely over after injuring ligaments in his left knee on Sunday (AFP)
Chiesa limped off the Stadio Olimpico pitch in the first half of Sunday's match, won 4-3 by Juve, and the club said in a statement the 24-year-old would require surgery on his anterior cruciate ligament.
Juve did not say for how long Chiesa would be out but ACL injuries require months of recovery time, and Italian media have pronounced his season over.
That means he will also miss Italy's bid to qualify for the 2022 World Cup via the playoffs, which begins against North Macedonia in late March.
His absence will be a big blow to Italy coach Roberto Mancini as he was one of the stars of the Azzurri's triumph at Euro 2020 last summer.
Chiesa, who had just returned to action after weeks on the sidelines with a muscle injury, has scored four times for Juve this season in all competitions.
(For more sports news and updates, follow Ahram Online Sports on Twitter at @AO_Sports and on Facebook at AhramOnlineSports.)