File Photo: Wolverhampton goalkeeper Jose Sa gestures during the match with Arsenal on 10 February, 2022. Photo courtesy of Wolverhampton Facebook page.
The Portuguese soccer federation said Lopes has been ruled out because of an undisclosed injury.
Portugal coach Fernando Santos also had to replace Pepe with Tiago Djalo on Monday after the veteran defender tested positive for COVID-19.
Portugal hosts Turkey in Porto. The will play either Italy or North Macedonia in the final round of the qualifying playoffs if it advances.
It wasn't yet clear if the 39-year-old Pepe would be able to play the second qualifier next week if Portugal advanced.
Santos also won't be able to count on the injured Ruben Dias, the team's other regular starting central defender.
Midfielder Ruben Neves is also unavailable because of an injury.
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