PSG coach Christophe Galtier opted not to rest the attacking trio against Auxerre as the champions seek to extend their lead at the top of the table before the break for the tournament in Qatar.
The Parisians started the game two points ahead of Lens, who won 2-1 at home against Clermont on Saturday, with Rennes a further five points adrift.
Messi, who tasted glory in the Copa America last year, will be hoping to fire Argentina to World Cup glory for the first time since 1986.
Mbappe will be one of the key players for defending champions France in Qatar and Neymar will spearhead Brazil's push for a sixth World Cup crown.
The tournament starts with a match between hosts Qatar and Ecuador on November 20.
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