Newcastle's Dan Burn, left, challenges Liverpool's Dominik Szoboszlai during the English Premier League soccer match between Liverpool and Newcastle United at Anfield in Liverpool. AP
With suspended boss Arne Slot watching from the Anfield stands, Liverpool opened up a massive 13-point lead over second-placed Arsenal thanks to goals from Dominik Szoboszlai and Alexis Mac Allister.
In Wednesday's other action, Manchester City won 1-0 at Tottenham, while 10-man Manchester United held on to beat lowly Ipswich 3-2.
But it is Liverpool who continue to hog the Premier League spotlight as an almost-flawless campaign approaches a memorable climax.
The Reds look certain to win the Premier League for the first time since 2020, which will move them level with Manchester United on a record-equalling 20 English titles.
Having won 2-0 at fading champions City on Sunday 24 hours after Arsenal lost to West Ham, Slot's men kept their foot on the gas to turn the title race into a procession.
Szoboszlai netted with a clinical finish in the 11th minute and Mac Allister's fine strike in the 63rd minute made it 20 wins and just one defeat from 28 league games this term.
In his first season after replacing Jurgen Klopp, Slot has made an astonishing impact, which could yet include Champions League and League Cup glory as well.
The Reds play Paris Saint-Germain in the Champions League last 16 first leg next week and face a rematch with Newcastle at Wembley in the League Cup final on March 16.
Arsenal boss Mikel Arteta had said his side would concede the title "over my dead body".
The Gunners have a game in hand on Liverpool, but Arteta may have to accept the stalemate at the City Ground was the final nail in the coffin for Arsenal's attempt to win a first title since 2004.
The toothless Gunners, playing without a recognised striker, managed just one shot on target at the City Ground, with Riccardo Calafiori hitting the post in the first half.
Third-placed Forest's surprise challenge for Champions League qualification has also hit the rocks after just one win from their last five matches.
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