
Arsenal's Ecuadorian defender #05 Piero Hincapie (L) vies with Chelsea's Brazilian striker #20 Joao Pedro (R) during the English Premier League football match between Chelsea and Arsenal at Stamford Bridge in London. AFP
Chelsea midfielder Moises Caicedo was sent off in the 38th minute at Stamford Bridge for a crude foul on Merino that caught the midfielder on his ankle.
Despite Caicedo's dismissal, Trevoh Chalobah headed Chelsea from Reece James' corner into the lead in the 48th minute.
But Merino's close-range header from Bukayo Saka's cross in the 59th minute ensured Arsenal emerged unscathed from a bruising encounter between the title rivals.
Arsenal are five points clear of second-placed Manchester City, who beat Newcastle on Saturday, and sit six points above third-placed Chelsea.
The Gunners remain the favourites to win their first Premier League crown since 2004, but Chelsea's combative display suggested they could emerge as the biggest threat to the Gunners' title aspirations.
Arsenal are unbeaten in 17 games in all competitions, winning 14 of those matches, while Chelsea have gone seven matches without losing in all competitions.
Isak had failed to score in his five top-flight appearances since making a British record £125 million ($165 million) move from Newcastle in September.
The Sweden forward banished that drought with only his second goal in 11 games in all competitions for the Reds, following his maiden strike in a League Cup win against second-tier Southampton.
Cody Gakpo bagged Liverpool's second goal in stoppage time to secure their first win in four games in all competitions.
"It's very important for us as a team that we went 1-0 up, but I think it was also important for him because I think it was his third or fourth chance of this game," said Liverpool manager Arne Slot.
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