England face Wales on March 26, however Ferguson does not expect United defender Ferdinand -- who has been out of action since January -- to be fit in time.
"Rio has been doing a bit of running. He will be ready for the game after the internationals," said Ferguson.
"I wouldn't have thought he would have a chance before that. I don't think it would be wise for him to be called up by England. He hasn't played for us since January."
It leaves England manager Fabio Capello with a dilemma concerning who will skipper the Three Lions.
Ferdinand's expected absence, along with that of vice-captain Steven Gerrard, means Capello could offer the armband back to former skipper John Terry.