Novak Djokovic of Serbia (Photo: AP)
Nadal has won at Monte Carlo since 2005, and gone on to win the French Open every year except 2009.
But the six-time French Open champion has lost in seven straight finals to Djokovic, including the last three Grand Slam finals. Djokovic also handed Nadal his only two losses on clay last year, in the Madrid and Rome Masters.
Victory in Monte Carlo would be even sweeter for Djokovic, given that Nadal has won 37 consecutive matches in Monte Carlo and holds a 39-1 record.
The second-ranked Nadal is without a title since winning last year's French Open. He was also without a title in 2011 heading into Monte Carlo, then went on to win here and the French Open.
Unlike the oppressive atmosphere of jam-packed Roland Garros in bustling western Paris, the Monte Carlo Country Club's peaceful clay-courts overlooking the glittering Mediterranean sea are like a second home for Nadal.
It's where it all started for him as a 16-year-old, when an astonishing victory over former French Open champion Albert Costa propelled him into the spotlight. Nine years later, he is the star everyone wants to beat.
Not even 16-time Grand Slam champion Roger Federer could topple him here. At the peak of his form, the Swiss star still found no answer, losing to Nadal in the final from 2006-08.
Others, like Fernando Verdasco, were simply routed - the Spaniard managing to take just one game off Nadal in the 2010 final.
But the top-ranked Djokovic, who lost to Nadal in the 2009 Monte Carlo final, is ready to end the Spaniard's run, and maintain his recent dominance over the 10-time Grand Slam champion.
Overall, Nadal leads their series 16-14 but has not beaten Djokovic since a group-stage match at the 2010 ATP Finals in London.
With six weeks to go until the French Open, the 24-year-old Serb knows he can dent Nadal's confidence and keep his momentum going by winning at Monte Carlo.
Djokovic opens his campaign in the second round against either Andreas Seppi or a qualifier, while Nadal faces Radek Stepanek or Jarkko Nieminen.
Britain's Andy Murray, who took a set off Nadal in an exciting semifinal last year, is seeded third and plays Serb Viktor Troicki in round two. Murray could meet No. 6 Tomas Berdych of the Czech Republic in the quarterfinals.
No. 4 Jo-Wilfried Tsonga returns to the Country Club a week after France's 3-2 loss to the United States in the Davis Cup quarterfinals. He lost to big-serving American John Isner.
Federer and Isner are not playing in the tournament.
Meanwhile, there were comfortable wins for Troicki and Croatia's Ivan Dodig in the first round on Sunday.
Troicki beat Monaco's Jean-Rene Lisnard 6-3, 6-1, while Dodig broke countryman Ivan Ljubicic's serve six times en route to a 6-0, 6-3 win.
It was the last match of the 33-year-old Ljubicic's career, and he struggled to contain his emotions.
''Tough day for me, I mean, both on the court and off the court. I had my mind everywhere else except on the tennis court,'' said Ljubicic, who won 10 titles and rose to a career-high ranking of No. 3 in 2006. ''It's the end of something beautiful for me.''
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