The 37-year-old, Big Ramy defeated the 2019 Mr. Olympia champion Brandon Curry of America and Hadi Choopan of Iran to snatch the 2021 title.
"Sandow (Mr. Olympia trophy) is at home and it will remain here for a very long time," Big Ramy wrote on his faccebook page.
"Thank you to all my fans around the world, I made it because of your love and support," the Mr. Olympia title winner added.
Big Ramy made eight appearances in the Mr. Olympia competition as he finished in the runner-up place four years ago.
After winning last year's title, the Egyptian bodybuilding star became the first non-American to win the title since British champion Dorian Yates in 1997 to prove himself as the best bodybuilder in the world.
The 2021 Mr. Olympia top five:
1. Big Ramy (Egypt) $400,000
2. Brandon Curry (USA) $150,000
3. Hadi Choopan (Iran) $10,000
4. Hunter Labrada (USA) $40,000
5. Nick Walker (USA) $35,000