Bolt, fresh from his second successive triple gold haul at the Olympics, came into the final stretch just ahead of compatriot Nickel Ashmeade on his inside.
And then the imposing 26-year-old switched on the afterburners in his drive phase to ensure a comfortable win in his favoured event.
Ashmeade, who did not compete in the Olympics after only finishing fourth in the Jamaican trials, claimed second in a personal best of 19.85sec.
Jamaicans also took third and fourth spots in the shape of Jason Young (20.08) and Olympic bronze medallist Warren Weir (20.18).
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