Grey hair gene could be switched off, say scientists

Reuters , Tuesday 5 Apr 2016

Scientists identify the gene that causes grey hair and say the discovery could lead to new ways of delaying or preventing it.


No matter who you are; for most of us grey hair is an inevitable part of getting older.

But what if you could switch off the gene that causes it? For the first time, scientists have identified a gene called IRF4 as the culprit behind grey hair.

DNA samples from over 6,000 volunteers were collected in Latin America; chosen for the diverse ancestry of its inhabitants. And it turns out if you have your roots in Europe, grey hair is much more likely.

"This genetic variant of IRF4 has two forms; one form is present world-wide and the other form is present only in Europeans. And we saw that this particular European specific form gives you almost double the chance of hair greying,' says Dr Kaustubh Adhikai , University Colledge London.

The gene IRF4 helps regulate melanin in the body, which determines - among other things - hair colour. Age and environmental factors will, of course, influence how quickly IRF4 triggers hair greying.

But the researchers say their discovery could lead to a treatment that could stop it in its tracks.

"Switching off a gene is of course feasible, the issue is whether it will have the desired effect and whether it's the right thing to do... But in terms of trying to develop a therapy to delay or prevent hair greying, that is something that is potentially feasible; yes," says Dr  Andres Ruiz-Linares.


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