At least 63 albinos, including children, are known to have been killed, mostly in the remote northwest of the country.
"We believe there are hundreds and hundreds of killings in Tanzania, but only a small number are being reported to the police," Peter Ash, founder and director of Under The Same Sun (UTSS), told Reuters.
"There is belief that if you have relations with a girl with albinism, you will cure AIDS. So there are many girls with albinism who are being raped in this country because of this belief, which is a false belief."
Around 1.4 million Tanzanians among a population of 40.7 million have the HIV virus that leads to AIDS.
Albino hunters kill their victims and harvest their blood, hair, genitals and other body parts for potions that witchdoctors say bring luck in love, life and business.
"(It is believed) a person with albinism is a curse. They are from the devil, they are not human, they do not die, they simply disappear," said Ash.
The Tanzanian government says it is determined to halt the macabre killings, but has been widely criticized for inaction.