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Sunday, 25 July 2021

Chemo possible for pregnant cancer patients

A Belgian-led study of 70 children shows exposure to chemotherapy in the early stages of pregnancy will not affect the healthy development of the foetus and in some circumstances radiotherapy is even possible

AP, Sunday 12 Feb 2012
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Only about 1 in 1,000 pregnant women face this dilemma but doctors fear that more will because the risk of cancer rises with age, and more women are delaying having children until they're older.

Doctors have long worried about how to balance treating a pregnant woman with cancer and the need to protect her foetus from the effects of toxic cancer drugs and radiation treatments, and whether it is safe to continue a pregnancy in certain situations. A series of papers published in the journals Lancet and Lancet Oncology make several key contributions:

- A Belgian-led study of 70 children in Europe exposed to chemotherapy while they were in the womb found they developed just as well as other children, according to tests on their hearts, IQ and general health. They were assessed at birth, 18 months, and every few years until age 18.

- Chemotherapy after the first trimester is possible, using extra ultrasounds to ensure the baby is developing properly. Radiation therapy is best done in the first two trimesters, when the baby is small enough to be covered with a lead blanket, according to a review of previous studies, led by Belgian researchers.

- Ending the pregnancy doesn't improve chances for the mother, the same study found.

- The type of cancer seems to matter: An Israeli analysis of past research suggested pregnant women with blood cancers might want to terminate an early pregnancy when chemotherapy can't be delayed.

- Another review of previous studies by French and American researchers concluded doctors should aim to preserve pregnancy in women with cervical or ovarian cancers where possible.

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