(All times GMT+2)
Friday 22 September
Club Sportif Sfaxien (Tunisia) 1-0 (4-5pens) Fath Union Sport (Morocco) (0-1)
Scorers: Karim El-Awadi 23pen
Fath Union Sport booked a place in the semifinals after winning 5-4 on penalties
Saturday 23 September
Zesco United FC (Zambia) 2-2 Supersport United FC (South Africa) 0-0
Scorers: John Ching'andu 4, / Thuso Phala 34, 90+2
Supersport United FC reached the semifinals on the away goal rule
Sunday 24 September
TP Mazembe (DR Congo) 5-0 Al Hilal Elobied (Sudan) (2-1)
Scorers: Jean Kasusula 39, Adama Traore 49, Malango Ngita 55, Elia Meschack 84, Issama Mpeko 90
TP Mazembe reached the semifinals after winning 7-1 on aggregate
Club Africain (Tunisia) 2-0 Mouloudia Club D'Alger (Algeria) (0-1)
Club Africain reaches the semifinals after winning 2-1 on aggregate.
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